CAS 165047-24-5: 2,4,5-Trifluorobenzaldehyde

2,4,5-Trifluorobenzaldehyde is a perfluorinated compound with a synthetic origin. It has been shown to be reactive towards nucleophiles and electron-deficient molecules. The asymmetric synthesis of 2,4,5-trifluorobenzaldehyde is achieved by the reaction of β-amino acid ethyl bromoacetate with sodium hydroxide in ethanol followed by photolysis of the resulting α-hydroxyketone. The photochemical properties of 2,4,5-trifluorobenzaldehyde have been studied and it was found that the compound exhibits selective absorption in the ultraviolet region. 2,4,5-Trifluorobenzaldehyde can be used for the synthesis of β-amino acid derivatives with various substituents at C2 position. Additionally, this molecule can be used as a building block for other organic compounds that are important in biomolecular research.

Applications 2,4,5-Trifluorobenzaldehyde is a reactant in the enantioselective synthesis of (R)-selegiline, an anti-Parkinson's drug, (S)-benzphetamine, an anti-obesity agent, and (S)-sitagliptin, an anti-diabetic drug. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Dey, S., Sudalai, A.: Tetrahedron-Asymmetr., 26, 67 (2015)

2,4,5-Trifluorobenzaldehyde