CAS: 166403-66-3

Tenofovir diphosphate is an antiviral compound, which is a key active metabolite derived from the prodrugs tenofovir disoproxil fumarate and tenofovir alafenamide, both originating from chemical synthesis. Its mode of action involves inhibiting the activity of HIV-1 reverse transcriptase by competing with the natural substrate, deoxyadenosine 5’-triphosphate, and causing chain termination after incorporation into viral DNA. This mechanism effectively prevents the replication of retroviral DNA, thus halting the progression of the infection. The primary uses and applications of Tenofovir diphosphate focus on the treatment and prevention of human immunodeficiency virus (HIV) infection. It plays a crucial role in antiretroviral therapy regimens due to its potency and high barrier to resistance. Additionally, it is employed in pre-exposure prophylaxis (PrEP) strategies for individuals at high risk of contracting HIV. The inclusion of Tenofovir diphosphate in combination therapies enhances the overall efficacy and durability of the antiviral response in patients, contributing significantly to the management of HIV/AIDS.

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TFV-DP inhibits DNA polymerases, mimics dATP, and is used by HIV-1's reverse transcriptase.

Stability Very Hygroscopic Applications rac Tenofovir-d6 Diphosphate Triethylamine Salt is an isotopic analog of Tenofovir Diphosphate Triethylamine Salt (T018525), which is a metabolite of Tenofovir (T018500). References Hazra, R., et al.: Antimicrob. Agents Chemother., 48, 124 (2004), Piketty, C., et al.: Antivir. Ther., 11, 213 (2006), Molto, J., et al.: Ther. Drug Monit., 29, 648 (2007),