CAS 166518-60-1: Avasimibe
Formula:C29H43NO4S
InChI:InChI=1S/C29H43NO4S/c1-17(2)22-14-25(20(7)8)27(26(15-22)21(9)10)16-28(31)30-35(32,33)34-29-23(18(3)4)12-11-13-24(29)19(5)6/h11-15,17-21H,16H2,1-10H3,(H,30,31)
InChI key:InChIKey=PTQXTEKSNBVPQJ-UHFFFAOYSA-N
SMILES:C(C(NS(OC1=C(C(C)C)C=CC=C1C(C)C)(=O)=O)=O)C2=C(C(C)C)C=C(C(C)C)C=C2C(C)C
Synonyms:- ((2,4,6-Tris(1-Methylethyl)Phenyl)Acetyl)Sulfamicacid2,6-Bis(1-Methylethyl)Phenylester
- 2,6-Di(Propan-2-Yl)Phenyl {[2,4,6-Tri(Propan-2-Yl)Phenyl]Acetyl}Sulfamate
- 2,6-Diisopropylphenyl (2-(2,4,6-triisopropylphenyl)acetyl)sulfamate
- Avasimin
- Ci 1011
- N-(2,6-Dipropan-2-Ylphenoxy)Sulfonyl-2-(2,4,6-Tripropan-2-Ylphenyl)Acetamide
- N-[(2,6-Diisopropylphenoxy)Sulfonyl]-2-(2,4,6-Triisopropylphenyl)Acetamide
- Pd 148515
- Sulfamic acid, N-[2-[2,4,6-tris(1-methylethyl)phenyl]acetyl]-, 2,6-bis(1-methylethyl)phenyl ester
- Sulfamic acid, [[2,4,6-tris(1-methylethyl)phenyl]acetyl]-, 2,6-bis(1-methylethyl)phenyl ester
- Avasimibe
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Avasimibe
CAS:Formula:C29H43NO4SPurity:>98.0%(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:501.73Avasimibe
CAS:Avasimibe is a drug that inhibits the enzyme DPP-IV and prevents the degradation of DPP-IV substrates, such as peptides, proteins, and lipids. It also has other pharmacological effects such as inhibiting the mitochondrial membrane potential and inducing cell lysis. Avasimibe is used to treat atherosclerosis by preventing cholesterol from being absorbed by cells. It is also used in cancer treatment for its ability to inhibit viral life and reduce tumor size. In addition, avasimibe is able to inhibit BCR-ABL kinase activity and induce apoptosis in human leukemia cells.Formula:C29H43NO4SPurity:Min. 95%Color and Shape:PowderMolecular weight:501.72 g/molSulfamic acid, N-[2-[2,4,6-tris(1-methylethyl)phenyl]acetyl]-, 2,6-bis(1-methylethyl)phenyl ester
CAS:Formula:C29H43NO4SPurity:99%Color and Shape:SolidMolecular weight:501.721Avasimibe
CAS:Avasimibe (PD-148515): Oral ACAT inhibitor, prevents arterial cholesterol buildup; IC50: 3.3 μM. Hinders CYP2C9/1A2/2C19; IC50: 2.9/13.9/26.5 μM.Formula:C29H43NO4SPurity:98.39% - 99.91%Color and Shape:SolidMolecular weight:501.72Avasimibe
CAS:Applications Avasimibe is a selective inhibitor of Cholesterol Acyltransferase 1 and CYP2C9. Avasimibe is known to induce apoptosis of glioma cell lines as a model of glioblastoma. References Bemlih, S., et al.: Cancer. BIol. Therap., 9, 1025 (2010); Fahmi, O.A., et al.: Drug. Meta. Disp. 38, 1605 (2010);Formula:C29H43NO4SColor and Shape:White SolidMolecular weight:501.72
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