CAS 1672-58-8: 4-(Formylamino)antipyrine

METAMIZOLE IMPURITY A CRS

N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)formamide

Applications A metabolite of Dipyrone, a nonsteroidal anti-inflammatory drug. References Kujubu, D., et al.: J. Biol. Chem., 266, 12866 (1991), Campos, C., et al.: Eur. J. Pharm., 378, 339 (1999), Michaux, C., et al.: Eur. J. Med. Chem., 40, 1316 (2005),

4-Formylamino antipyrine (4-FA) is a pyrazole that has been shown to be effective in the treatment of rheumatoid arthritis. 4-FA inhibits the metabolism of ethylene diamine, which prevents the formation of reactive metabolites that inhibit DNA and protein synthesis. The IC50 value for 4-FA was determined using a monoclonal antibody as a metabolic marker. The plasma concentration-time curve for 4-FA was determined by LC/MS/MS analysis at different concentrations and time intervals. This drug is metabolized by liver cells, which produce active metabolites that can be detected in urine samples following administration. It has been shown to have pharmacokinetic properties similar to those of carbamazepine and is used for the same indications. 4-FA also shows antiinflammatory effects through its inhibition of prostaglandin synthesis.