CAS: 16848-12-7

6-Amino-9-(1-deoxy-β-D-psicofuranosyl)purine (6APdP) is a nucleoside with potential chemotherapeutic activity. It has been shown to suppress the expression of genes that encode proteins involved in cell proliferation and differentiation, including suppressor genes. 6APdP is activated by methyladenosine monophosphate kinase and binds to the ribose hydroxyl group on RNA molecules. This molecule has been shown to inhibit hepatitis B virus replication and cancer cell growth in animal models. The hydrogen bonding interactions between 6APdP and the ribose hydroxyl group are stronger than those associated with ethylene diamine tetraacetic acid (EDTA). 6APdP is also an inhibitor of protein synthesis.