2-Hydroxy-4-iodobenzoic acid, with the CAS number 16870-28-3, is an organic compound that belongs to the class of benzoic acids. It features a hydroxyl group (-OH) and an iodine atom attached to a benzene ring, which is further substituted with a carboxylic acid group (-COOH). This compound is characterized by its white to off-white crystalline appearance and is soluble in polar solvents such as water and alcohols, owing to the presence of the hydroxyl and carboxylic acid functional groups. The iodine substitution can influence its reactivity and biological activity, making it of interest in various chemical and pharmaceutical applications. Additionally, 2-hydroxy-4-iodobenzoic acid may exhibit properties such as antimicrobial or anti-inflammatory effects, which are common in compounds with similar structures. Its synthesis typically involves the iodination of a suitable precursor followed by hydroxylation and carboxylation steps. As with many organic compounds, handling should be done with care, considering potential hazards associated with iodine and acidic substances.

2-Hydroxy-4-iodobenzoic acid

16870-28-3: 2-Hydroxy-4-iodobenzenecarboxylic acid, 4-Iodosalicylic Acid, Benzoic acid, 2-hydroxy-4-iodo-, NSC 109096, Salicylic acid, 4-iodo-, 2-Hydroxy-4-iodobenzoic acid

2-Hydroxy-4-iodobenzoic acid is a ligand that binds to the uncoupling protein (UCP). UCP is a membrane protein found in the inner mitochondrial membrane of cells, which causes an increase in proton leak across the inner mitochondrial membrane. This increased proton leak leads to an increased production of ATP, but does not use oxygen, as opposed to oxidative phosphorylation. 2-Hydroxy-4-iodobenzoic acid has been shown to uncouple isolated rat liver mitochondria and is a potentiometric probe for measuring pH changes in mitochondria. 2-Hydroxy-4-iodobenzoic acid also binds with salicylic acid, causing it to release electrons that are used in the electron transport chain.

CAS 16870-28-3: 2-Hydroxy-4-iodobenzoic acid

2-Hydroxy-4-iodobenzoic acid

Ref: 10-F012739

2-Hydroxy-4-iodobenzoic acid

Ref: 3D-FH146148

4-Iodosalicylic acid

Ref: 54-OR41184

Benzoic acid, 2-hydroxy-4-iodo-

Ref: IN-DA001Y95