Desloratadine Pyridine N-oxide, with the CAS number 169253-26-3, is a derivative of desloratadine, which is an antihistamine used primarily for the treatment of allergic symptoms. This compound features a pyridine N-oxide functional group, which contributes to its chemical properties and biological activity. Desloratadine itself is known for its selective antagonism of peripheral H1 receptors, providing relief from allergy symptoms without significant sedation, as it is less likely to cross the blood-brain barrier. The N-oxide modification may influence its pharmacokinetics and metabolism, potentially affecting its efficacy and safety profile. In terms of physical properties, it is typically a solid at room temperature, with solubility in polar solvents. The compound's stability, reactivity, and interactions with other substances can vary based on its molecular structure and the presence of functional groups. As with any chemical substance, proper handling and safety precautions are essential, particularly in laboratory or pharmaceutical settings.

Desloratadine Pyridine N-oxide

169253-26-3: 8-chloro-11-piperidin-4-ylidene-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine 1-oxide

Compounds containing an unfused pyridine ring in the structure, nesoi

Desloratadine N-oxide (8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine 1-Oxide)

Desloratadine N-oxide is a sulfate prodrug of desloratadine. It is metabolized to the active form, desloratadine, by esterases in the blood and liver. Desloratadine N-oxide has been shown to be more potent than the parent compound in inhibiting histamine release from mast cells, as well as having a longer plasma half-life. This product may be used for treating seasonal allergic rhinitis and chronic idiopathic urticaria.

CAS 169253-26-3: Desloratadine Pyridine N-oxide

Desloratadine N-oxide (8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine 1-Oxide)

Ref: 45-1A02130

Desloratadine N-Oxide

Ref: 3D-UGA25326

Desloratadine N-Oxide

Ref: TR-D290260

Desloratadine Pyridine N-Oxide

Ref: 4Z-L-1015

Desloratadine N-oxide

Ref: ST-EA-CP-D15026