CAS: 1700663-41-7

EPZ020411 is a synthetic, small-molecule compound that inhibits the methylation of histones and their associated proteins. EPZ020411 has been shown to inhibit tumor growth in xenograft models. The most effective dose of EPZ020411 was found to be 10 μM for inhibiting protein methylation and decreasing mitochondrial membrane potential. EPZ020411 is a reactive molecule that may be used as a probe for studying the biological sample or cellular system in which it is incubated.

EPZ020411 is a specific and effective inhibitor of PRMT6 (IC50=10 nM).