CAS 1711-06-4: m-Toluoyl chloride

m-Toluoyl chloride has been used to derivatize the C1-C4 aliphatic amines for their determination in air by HPLC. It has been used in determination of atmospheric ammonia by denuder-sampling and HPLC-UV detection. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

m-Toluoyl Chloride

m-Toluoyl chloride

m-Toluoyl Chloride is an organic compound that is used as a reagent in the synthesis of a variety of chemical compounds. It is also used in clinical research to produce polyclonal antibodies. m-Toluoyl Chloride undergoes nucleophilic attack and forms amines, which are then acylated with chloroformates or carbonyl compounds to form molecules such as benzamides, pyridinium salts, and quaternary ammonium salts. The reaction mechanism for this process has been elucidated through molecular modeling and X-ray crystallography studies.

m-Toluoyl chloride is a bioactive chemical.

Applications m-Toluoyl Chloride is used as a reagent in the synthesis of glycine benzamides as oral GPR139 receptor agonists. m-Toluoyl Chloride is also used in the preparation of colchicine derivatives which have potent anticancer activity and reduced P-glycoprotein induction liability. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Dvorak, C.A., et al.: ACS Med. Chem. Lett., 6, 1015 (2015); Singh, B., et al.: Org. Biomol. Chem., 13, 5674 (2015)

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.