CAS 171364-82-2: 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile

Applications 4-(Cyanophenyl)boronic Acid Pinacol Ester is used to prepare arylparacyclophanes via Suzuki aryl cross-coupling of bromoparacyclophane with arylboronic acid and arylboronates. It’s also used to prepare tyrosine-modified analogs of α4β7 integrin inhibitor biotin-R8ERY. References Roche, A., et al.: Org. Biomol. Chem.,, 3, 515 (2005); Papst, S., et al.: Bioorg. Med. Chem., 20, 5139 (2012)

4-Cyanophenylboronic acid pinacol ester is a protonated form of retinoic acid that has been activated with an optical acceptor. This compound has been shown to be able to cross-couple with aryl boronic acids under thermally activated conditions, as well as react with hydroxyl groups or halides. The use of this compound in clinical development depends on the desired properties. If the desired property is aryl boronic acids, then this compound is best used in cross-coupling reactions. Alternatively, if the desired property is hydroxyl group or halides, then this compound can be used in reactions involving these functional groups.

4-Cyanobenzeneboronic acid, pinacol ester

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This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.