CAS 171440-18-9: 2-[(R)-{[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl}sulfinyl]-1H-benzimidazole-sodium (1:1)

Rabeprazole sodium is a proton pump inhibitor that inhibits gastric acid secretion by blocking the final step of acid production. Rabeprazole sodium is a white to off-white crystalline powder with a molecular weight of 579.87 and a melting point of 137-138°C. It has an acetate extraction process, which involves the conversion of alcohols to their corresponding salts, followed by precipitation with acetic acid. The synthetic process for rabeprazole sodium involves the reaction of maleic anhydride and protonated benzene or phenol. The powder diffraction spectrum for this molecule exhibits peaks at 2θ = 6.6°, 7.7°, 8.8°, 12.2°, 15.1°, 16.9°, 18° and 19°. Maleic anhydride is used as a starting material in the synthesis process and can be synthesized from ethylene glycol and phthalic anhydride

Applications A partially reversible gastric proton pump inhibitor. References Moda, T., et al.: Lett. Drug Des. Discov., 4, 502 (2007), Belaz, K., et al.: J. Pharm. Biomed. Anal., 47, 81 (2008),