CAS: 172018-16-5

Applications 13-epi-10-Deacetyl Baccatin III is a new analog of 10-Deacetylbaccatin III (D198250). References Gabetta, B., et al.: J. Natural Products, 58, 1508 (1995),

13-Epi-10-deacetyl baccatin III is a diterpenoid compound, which is an intermediate in the biosynthetic pathway of taxoids. It is derived primarily from the needles and bark of the European yew tree, Taxus baccata, and related species. The compound is a part of a complex chemical structure essential for the formation of important chemotherapeutic agents. The mode of action of 13-Epi-10-deacetyl baccatin III primarily involves its role as a precursor in the semisynthetic production of taxanes. Taxanes exert their effects by stabilizing the microtubule structure, preventing depolymerization, and thereby inhibiting cell division. This mechanism is crucial in the disruption of cancer cell proliferation. Applications of 13-Epi-10-deacetyl baccatin III are mainly focused on its role in the synthesis of chemotherapeutic agents such as docetaxel and paclitaxel, which are extensively used in the treatment of various cancers. The compound's availability and modifications offer a significant advantage in the fight against cancer, aiding in the development of more effective and targeted therapies.