CAS: 172617-84-4

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Impurity Azithromycin EP Impurity I Stability Hygroscopic Applications N’-Desmethyl Azithromycin (Azithromycin EP Impurity I) is a metabolite of Azithromycin (A927000) as potential anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agent. References Bright, G., et al.: J. Antibiot., 41, 1029 (1988), Goldman, R., et al.: Antimicrob. Agents Chemother., 34, 426 (1990), Gandhi, R., et al.: J. Pharm. Biomed. Anal., 23, 1073 (2000),

N'-Desmethyl azithromycin is a semi-synthetic derivative antibiotic, which is derived from the chemical modification of azithromycin, a macrolide antibiotic sourced originally from the bacterium *Streptomyces erythreus*. It functions primarily by inhibiting bacterial protein synthesis, binding specifically to the 50S ribosomal subunit, which results in the prevention of transpeptidation and translocation processes during translation. This action effectively halts bacterial growth, rendering it bacteriostatic. The primary applications of N'-Desmethyl azithromycin are rooted in its antibacterial properties. It is utilized in the research context to study resistance mechanisms and pharmacokinetics of azithromycin and its derivatives. Additionally, its unique structure allows exploration into formulation strategy, improved bioavailability, and extended spectrum of macrolide antibiotics. While not typically used in clinical settings independently, it serves as an important component in the development of new antibiotics and understanding the metabolism and efficacy of macrolide antibiotics.

CP-64434 hydrate is an antibiotic; anti-proliferative HDAC inhibitor.