CAS 17303-67-2: Goniothalamin

Goniothalamin induces apoptosis in various cancer cell lines and has gastroprotective activity.

Goniothalamin is a bioactive styryl-lactone, which is a naturally occurring compound derived from the Goniothalamus plant species, commonly found in Southeast Asia. It is recognized for its intriguing biological properties, particularly its potential anticancer effects. Goniothalamin exerts its mode of action primarily through the induction of apoptosis in cancerous cells. It initiates cell death by disrupting mitochondrial membrane potential, activating caspase enzymes, and promoting the release of cytochrome c into the cytosol. Additionally, it is reported to modulate various signaling pathways involved in cell survival and proliferation. Goniothalamin is leveraged primarily in scientific research, with its applications focused on the study of cancer treatment mechanisms. Researchers are investigating its efficacy in targeting specific cancer cell lines, understanding its pharmacokinetics, and exploring its synergy with conventional chemotherapy agents. While still largely in the research phase, its remarkable ability to selectively target cancer cells without affecting normal cells has spurred interest in further elucidating its potential therapeutic benefits. Such insights could eventually contribute to the development of novel anticancer strategies that harness the natural bioactivity of plant-derived compounds like goniothalamin.