CAS 17320-10-4: 4β-Hydroxycholesterol

4β-hydroxy Cholesterol is a useful organic compound for research related to life sciences. The catalog number is T21530 and the CAS number is 17320-10-4.

Applications A metabolite of Cholesterol. It is formed from Cholesterol by the drug-metabolizing enzyme cytochrome P 450 3A4. A potential ligand for the nuclear receptor LXR and also a new endogenous CYP3A marker. References Breuer, O., et al.: J. Lipid Res., 36, 2275 (1995), Pikuleva, I., et al.: J. Biol. Chem., 273, 18153 (1998), Chawla, A., et al.: Science, 294, 1866 (2001), Bodin, K., et al.: J. Biol. Chem., 276, 38685 (2001),

4b-Hydroxy cholesterol is a sterol that is found in human serum and rat liver microsomes. It has been shown to be a potent inducer of CYP3A4, which is an important enzyme in the metabolism of many drugs. 4b-Hydroxy cholesterol has also been shown to induce transcriptional regulation by binding to the sterol regulatory element binding protein (SREBP) and activating it. This activation results in the increased production of cholesterol and other sterols by upregulating transcription of genes that are involved in cholesterol synthesis. 4b-Hydoxy cholesterol has been shown to have anti-inflammatory properties due to its inhibition of triclosan and clinical studies show that it can reduce serum levels of total cholesterol and low density lipoprotein (LDL) cholesterol in women.