CAS: 173897-44-4

Y-33075 dihydrochloride is a potent selective Rho-associated kinase (ROCK) inhibitor, which is synthesized chemically. It specifically targets ROCK enzymes involved in the regulation of the cytoskeleton by phosphorylating proteins that control smooth muscle contraction, cell migration, and other critical cellular processes. Y-33075 dihydrochloride works by inhibiting the ROCK pathway, leading to alterations in cell shape, motility, and apoptosis. This compound is widely used in scientific research, particularly for studies focused on cardiovascular diseases, cancer metastasis, and ocular hypertension. Its role in modulating vascular tone and affecting endothelial permeability makes it a valuable tool for exploring treatment strategies for glaucoma and hypertension. Researchers also utilize it to investigate the molecular mechanisms behind cell motility and proliferation. By selectively inhibiting ROCK activity, Y-33075 dihydrochloride helps unpack the intricate pathways involved in major physiological and pathological processes.

(R)-4-(1-Aminoethyl)-N-(1H-Pyrrolo[2,3-B]Pyridin-4-Yl)Benzamide Dihydrochloride

Y-33075 dihydrochloride

Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM).