CAS 17391-18-3: Corynoxine B

Corynoxine B is a bioactive compound, specifically an alkaloid, which is derived from the plant Uncaria rhynchophylla, commonly found in traditional Chinese medicine. Its mode of action involves the modulation of autophagy pathways, enhancing the degradation and clearance of damaged proteins and dysfunctional cellular components. This mechanism is crucial in maintaining cellular homeostasis, especially in neurodegenerative conditions. Corynoxine B has garnered interest for its potential applications in neuroprotection, owing to its ability to induce autophagy. Studies suggest its promising role in mitigating the pathologies associated with neurodegenerative diseases such as Parkinson's and Alzheimer's. By promoting the catabolic process of autophagy, Corynoxine B may help clear toxic protein aggregates that are characteristic of these disorders. Research continues to investigate its efficacy and therapeutic potential, aiming to better understand its pharmacokinetics and optimize its use in clinical settings.

Natural alkaloid

Corynoxine B (Cory B), a natural alkaloid isolated from Uncaria rhynchophylla (Miq. ), is an autophagy inducer that enhances the activity of Beclin 1/VPS34 complex and increases autophagy by facilitating the interaction between Beclin 1 and HMGB1/2, which may ameliorate Alzheimer's disease. NVP-BAG956 (NVP-BAG956)