(E)-4-Hydroxy-2-hexenal, with the CAS number 17427-21-3, is an organic compound characterized by its aldehyde functional group and a hydroxyl group. This compound features a six-carbon chain with a double bond between the second and third carbons, which contributes to its reactivity and potential applications in organic synthesis. The (E) configuration indicates that the hydroxyl group and the aldehyde group are on opposite sides of the double bond, influencing its stereochemistry and biological activity. It is typically a colorless to pale yellow liquid with a distinctive odor, often associated with fresh or green notes. This compound is of interest in various fields, including flavor and fragrance chemistry, as well as in the study of natural products, where it may be found as a metabolite in certain plants. Its reactivity allows it to participate in various chemical reactions, making it a valuable intermediate in synthetic organic chemistry. Safety data should be consulted for handling and usage, as with all chemical substances.

(E)-4-Hydroxy-2-hexenal

17427-21-3: 4-Hydroxy-2E-hexenal, (E)-4-Hydroxy-2-hexenal, 2-Hexenal, 4-hydroxy-, (E)-, (2E)-4-Hydroxy-2-hexenal, 2-Hexenal, 4-hydroxy-, (2E)-

2-Hexenal, 4-hydroxy-, (2E)-

4-hydroxy-2(E)-hexenal

4-Hydroxy hexenal (4-HHE) are toxic aldehydes that are enriched in flavored gravies and cooking oils with storage time and elevated temperatures.

4-hydroxy Hexenal

(E)-4-Hydroxyhexenal is a reactive compound that has been shown to bind to the nuclear factor kappa B (NF-κB) and inhibit its binding activity. (E)-4-Hydroxyhexenal is also able to induce oxidative injury in cells and tissues, but the precise mechanism of this effect is unknown. This compound is found in biological samples such as blood plasma and urine and can be used as an analytical method for measuring oxidative stress levels. There are many biological properties associated with this molecule, including brain functions, mitochondrial functions, cellular physiology, and atherosclerotic lesion development. The most well-known effect of (E)-4-hydroxyhexenal is its ability to induce neuronal death by inducing mitochondrial membrane potential disruption.

CAS 17427-21-3: (E)-4-Hydroxy-2-hexenal

2-Hexenal, 4-hydroxy-, (2E)-

Ref: IN-DA001S4V

4-hydroxy-2(E)-hexenal

Ref: 48-12-0602

4-hydroxy Hexenal

Ref: TM-T36002

(E)-4-Hydroxyhexenal

Ref: 3D-FH172476