CAS 174532-82-2: 3-Hydroxynevirapine
Formula:C15H14N4O2
InChI:InChI=1S/C15H14N4O2/c1-8-11(20)7-17-14-12(8)18-15(21)10-3-2-6-16-13(10)19(14)9-4-5-9/h2-3,6-7,9,20H,4-5H2,1H3,(H,18,21)
InChI key:InChIKey=DANIONWINZEYME-UHFFFAOYSA-N
SMILES:CC1=C2C(N(C=3C(C(=O)N2)=CC=CN3)C4CC4)=NC=C1O
Synonyms:- 6H-Dipyrido[3,2-b:2′,3′-e][1,4]diazepin-6-one, 11-cyclopropyl-5,11-dihydro-3-hydroxy-4-methyl-
- 11-Cyclopropyl-5,11-dihydro-3-hydroxy-4-methyl-6H-dipyrido[3,2-b:2′,3′-e][1,4]diazepin-6-one
- 6H-Pyrido[3,2-b:2′,3′-e][1,4]diazepin-6-one, 11-cyclopropyl-5,11-dihydro-3-hydroxy-4-methyl-
- 3-Hydroxynevirapine
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Found 4 products.
3-Hydroxy Nevirapine
CAS:Controlled ProductApplications A metabolite of Nevirapine (N391275). References Rettie, A., et al.: J. Biol. Chem., 263, 13733 (1988), Lamson, M., et al.: Biopharm. Drug Dispos., 20, 285 (1999), Guengerich, F., et al.: Chem. Res. Toxicol., 14, 611 (2001), Lu, W., et al.: Drug Metab. Dispos., 36, 1624 (2008),Formula:C15H14N4O2Color and Shape:NeatMolecular weight:282.303-Hydroxy nevirapine
CAS:Formula:C15H14N4O2Purity:≥ 98.0%Color and Shape:Off-white to light yellow solidMolecular weight:282.303-Hydroxy nevirapine
CAS:Nevirapine is a non-nucleoside reverse transcriptase inhibitor that is metabolized by glucuronidation in the liver. 3-Hydroxy nevirapine is a major metabolite of nevirapine and can be used as an analytical marker for nevirapine in plasma samples. Nevirapine inhibits the cytochrome P450 system and can lead to hepatic impairment, which may be due to its ability to inhibit CYP3A4 and CYP2D6. Additionally, 3-hydroxynevirapine has been shown to have antiretroviral activity against HIV infection. The drug is used for the treatment of HIV infection in women who are pregnant or breastfeeding. Nevirapine's effectiveness in treating HIV may be due to its ability to inhibit viral protein synthesis and its strong affinity for nucleic acid sequences.Formula:C15H14N4O2Purity:Min. 95%Molecular weight:282.3 g/mol
