CAS 175033-36-0: 3-(Nitroxymethyl)phenyl 2-acetoxybenzoate

Nitroaspirin

NO-aspirin 1 is a nonsteroidal anti-inflammatory drug that has been shown to have anti-cancer and anti-ulcerative effects. It inhibits the activity of cyclooxygenase (COX) enzymes, which are responsible for generating prostaglandins. In vivo studies using a balloon injury model have shown that this drug can inhibit tumor growth by reducing cell proliferation and increasing apoptosis in skin cancer cells, as well as reduce bowel inflammation. NO-aspirin 1 also has been shown to inhibit the mitochondrial membrane potential in cardiomyocytes, resulting in an increased incidence of myocardial infarcts. This drug binds covalently to COX enzymes, inhibiting their function.

NCX 4016, a NO-donor nitro-derivative of Aspirin, inhibits COX-1 and triggers apoptosis in ovarian cancer cells by modulating EGFR/PI3K/STAT3 and Bcl-2.