3-Nitroquinoline is an organic compound characterized by a quinoline structure with a nitro group (-NO2) positioned at the 3rd carbon of the ring. It is a yellow to orange crystalline solid that is sparingly soluble in water but more soluble in organic solvents such as ethanol and acetone. The presence of the nitro group introduces both electron-withdrawing properties and potential for electrophilic substitution reactions, making it a versatile intermediate in organic synthesis. 3-Nitroquinoline exhibits fluorescence, which can be utilized in various applications, including as a fluorescent probe in biochemical assays. Additionally, it has been studied for its biological activities, including potential antimicrobial and anticancer properties. As with many nitro compounds, it is important to handle 3-nitroquinoline with care due to its potential toxicity and environmental impact. Proper safety measures should be taken when working with this compound in laboratory settings.

3-Nitroquinoline

Quinoline, 3-nitro-

3-Nitroquinoline is a nitro compound that has been shown to inhibit the production of the growth factor epidermal growth factor. It also inhibits the proliferation of cancer cells by binding to deoxyguanosine in DNA, resulting in DNA strand breakage. 3-Nitroquinoline is metabolized into a cytotoxic product, which leads to the death of cancer cells. The mechanism of action for this compound is through an electrostatic reaction with DNA, which causes depurination and results in cell death. 3-Nitroquinoline has been used as a potential treatment for polycythemia vera and myelodysplastic syndrome because it inhibits hepcidin production.

CAS 17576-53-3: 3-Nitroquinoline

Quinoline, 3-nitro-

Ref: IN-DA00215V

3-Nitroquinoline

Ref: 54-OR956394

3-Nitroquinoline

Ref: 10-F321374

3-Nitroquinoline

Ref: 3D-FN40647