![1-Azaspiro[4.5]decane](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fcas-image%2Fthumb-webp%2F72407-1-azaspiro-4-5-decane.webp&w=3840&q=75)
CAS 176-80-7: 1-Azaspiro[4.5]decane
Formula:C9H17N
InChI:InChI=1S/C9H17N/c1-2-5-9(6-3-1)7-4-8-10-9/h10H,1-8H2
InChI key:InChIKey=LGKNCSVHCNCJQG-UHFFFAOYSA-N
SMILES:C12(CCCCC1)CCCN2
Synonyms:- 2,2-Pentamethylenepyrrolidine
- Brn 0103872
- Nsc 19984
- Pyrrolidine, 2,2-(1,5-pentanediyl)-
- 5-20-04-00400 (Beilstein Handbook Reference)
- 1-Azaspiro[4.5]decane
- 1-Azaspiro(4.5)decane
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1-Azaspiro[4.5]decane
CAS:1-Azaspiro[4.5]decane is a compound that contains an azaspiro[4.5]decane skeleton with a formyloxy group at the 1 position and a hydroxyamine group at the 3 position. It has been shown to be an efficient method for the synthesis of peptidomimetics, which are compounds that have a peptide-like structure but are not peptides in the strict sense. The tricycle of 1-azaspiro[4.5]decane is formed through a hydrochloride salt, which is generated by hydrolysis of 1-azaspiro[4.5]decane with hydrochloric acid and then reduced with lithium aluminium hydride, or through reduction with hydrogen over palladium on charcoal in acetic acid. Hydroxyamination of 1-azaspiro[4.5]decane can be accomplished under basic conditions by treatment with ammonia and ethyl acetate, followed by hydroFormula:C9H17NPurity:Min. 95%Molecular weight:139.24 g/mol