Leptin is a hormone primarily produced by adipose (fat) tissue, playing a crucial role in regulating energy balance and body weight. It is a peptide hormone composed of 167 amino acids and is involved in signaling satiety to the brain, thereby influencing appetite and metabolism. The CAS number 177404-21-6 specifically identifies leptin, which is essential for maintaining body weight homeostasis. Leptin levels typically correlate with body fat; higher levels are found in individuals with increased fat stores, while lower levels are observed in those with reduced fat. This hormone also has implications in various physiological processes, including immune function and reproductive health. Dysregulation of leptin signaling is associated with obesity and metabolic disorders, highlighting its significance in both health and disease. Leptin's structure includes a helical conformation, which is critical for its interaction with the leptin receptor, initiating a cascade of signaling pathways that affect energy expenditure and appetite regulation.

leptin

177404-21-6: Leptin, Human, Recomb., Leptin, Human

Leptin is a protein hormone that is produced by adipose cells and functions to regulate energy balance. It has been shown to bind to receptors in the hypothalamus, which causes an increase in the production of adenosine, gamma-aminobutyric acid, and melanocortin. Leptin also regulates the expression of leptin receptor proteins, which are found on host cells. This active form is expressed at high levels in tissues such as bone marrow, skeletal muscle, and brown fat. The physiological function of this protein is not understood fully but it has been shown to have a role in regulating spatial memory function in mice.

CAS 177404-21-6: leptin

Leptin human

Ref: 3D-FL171650