CAS: 1781834-99-8

Filanesib is a small molecule that binds to ion channels and modifies the function of these channels. It is used as a research tool in cell biology and pharmacology. Filanesib binds to the extracellular domain of GABA A receptor and blocks the channel, leading to an increase in neuronal activity. This compound also has been shown to be a potent inhibitor of G protein-coupled receptors (GPCRs).

Filanesib (ARRY-520) inhibits KSP, triggering mitotic arrest and cell death in dividing tumor cells.