CAS 1799711-22-0: (1R)-3-(3,4-Dimethoxyphenyl)-1-[3-[[4-[[4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]butyl]amino]-1,4-dioxobutyl]amino]phenyl]propyl (2S)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-piperidinecarboxylate

dFKBP-1 is a potent and PROTAC-based FKBP12 degrader. dFKBP-1 incorporates the ligand SLF of FKBP12, the Thalidomide based cereblon ligand and a linker[1].

dFKBP-1 is a heat shock protein derived from Drosophila melanogaster, which is commonly used as a model organism in genetic and molecular biology research. This protein, known as Drosophila FK506-binding protein 1 (dFKBP-1), originates from Drosophila and is involved in essential cellular processes. The mode of action of dFKBP-1 involves its role as a molecular chaperone. It aids in protein folding and stabilization, especially under stress conditions such as heat shock. This protein exhibits peptidyl-prolyl cis-trans isomerase activity, catalyzing the isomerization of peptide bonds at proline residues, a crucial step in protein folding. dFKBP-1 is extensively used in research to study protein folding pathways, cellular stress responses, and the mechanisms underlying chaperone activities. Its applications extend to investigating signal transduction and cellular homeostasis. As part of applied research, dFKBP-1 can also serve as a tool in biological assays that require controlled protein stability and folding dynamics. Through these studies, insights into analogous human proteins and diseases associated with protein misfolding, such as neurodegenerative disorders, can be gained.