3-(Trifluoromethyl)benzamide is an organic compound characterized by the presence of a benzene ring substituted with a trifluoromethyl group and an amide functional group. Its molecular structure features a benzene ring with a trifluoromethyl group (-CF3) at the meta position relative to the amide group (-C(=O)NH2). This compound is typically a white to off-white solid at room temperature and is known for its relatively high stability due to the strong C-F bonds in the trifluoromethyl group. The presence of the trifluoromethyl group imparts unique electronic properties, enhancing the compound's lipophilicity and potentially influencing its reactivity and interactions in biological systems. 3-(Trifluoromethyl)benzamide is often utilized in various chemical syntheses and may serve as an intermediate in the production of pharmaceuticals and agrochemicals. Its CAS number, 1801-10-1, is a unique identifier used for regulatory and safety purposes. As with many fluorinated compounds, it is important to handle it with care due to potential environmental and health impacts.

3-(Trifluoromethyl)benzamide

1801-10-1: Benzamide, 3-(trifluoromethyl)-, alpha,alpha,alpha-Trifluoro-m-toluamide, m-Toluamide, α,α,α-trifluoro-, m-Trifluoromethylbenzamide, α,α,α-Trifluoro-m-toluamide, 3-(Trifluoromethyl)benzamide

3-(Trifluoromethyl)benzamide is an acyl halide that is a potent, selective, and orally bioavailable b-raf inhibitor. 3-(Trifluoromethyl)benzamide has been shown to inhibit the growth of colon cancer cells in vitro and in vivo. This compound also has the ability to cross the blood-brain barrier, which may be due to its high lipophilicity and low molecular weight. 3-(Trifluoromethyl)benzamide inhibits b-raf phosphorylation by blocking the cb2 receptor agonist binding site on b-raf. This inhibition results in decreased levels of c-jun N-terminal kinase (JNK), which leads to apoptosis. The pharmacophore for this drug includes a hydrophobic region that binds to the ATP binding site of b-raf and a carboxylic acid moiety that binds to the serine/threonine

CAS 1801-10-1: 3-(Trifluoromethyl)benzamide

3-(Trifluoromethyl)benzamide

Ref: 10-F007583

3-(Trifluoromethyl)benzamide

Ref: 3D-FT78782

3-(Trifluoromethyl)benzamide

Ref: 54-PC7506

Benzamide, 3-(trifluoromethyl)-

Ref: IN-DA0021PJ