CAS: 1801530-11-9

3-(5-(2-(1H-Imidazol-1-Yl)Acetyl)-2-Isopropoxyphenyl)-2-((4-(2-(4-Chlorophenoxy)Acetyl)Piperazin-1-Yl)Methyl)Quinazolin-4(3H)-One

View and buy Imidazole ketone erastin from TargetMol.Imidazole ketone erastin (IKE) is an inducer of ferroptosis. It has inhibition of the system Xc- cystine/glutamate transporter.Cited in 22 publications.

Imidazole ketone erastin is a small molecule compound, which is a synthetic analog derived from erastin. The origin of this compound is rooted in the study of ferroptosis, a form of regulated cell death characterized by iron-dependent lipid peroxidation. Imidazole ketone erastin functions by inhibiting the cystine/glutamate antiporter system Xc-, leading to the accumulation of lethal reactive oxygen species (ROS) within cells. The primary application of Imidazole ketone erastin lies in cancer research. It has demonstrated potential in inducing ferroptosis selectively in cancer cells, which often rely on system Xc- for cystine uptake and survival. This characteristic allows researchers to explore new therapeutic strategies for malignancies that exhibit resistance to conventional apoptosis-inducing treatments. By targeting the metabolic vulnerabilities of cancer cells, particularly those with high iron content, Imidazole ketone erastin provides a novel approach to understanding and potentially overcoming treatment resistance mechanisms. Its unique mode of action makes it an invaluable tool for studying the biochemical pathways of ferroptosis and expanding the therapeutic landscape in oncology research.

Imidazole ketone erastin