CAS 181219-01-2: Pyridine-4-boronic acid pinacol cyclic ester

Pyridine-4-boronic acid, pinacol ester

It is employed in the synthesis of new pyridazino[4,5-b]indol-4-ones and pyridazin-3(2H)-one analogs as DYRK1A inhibitors. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is a bifunctional inhibitor of the efflux pump of MDR cells. It has been shown to inhibit the function of efflux pumps in MDA-MB-231 cells. This inhibition is due to 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine binding to the transmembrane domains and blocking the transport of drugs. This inhibition has also been seen in vivo and in vitro when used in combination with other antimicrobial agents such as clofazimine. 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine’s inhibitory effects on efflux pumps have been shown using photoc

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.