CAS 181225-33-2: (20E)-Ginsenoside F4

Ginsenoside F4 induces apoptosis in JK cells by causing mitochondrial dysfunction and altering Bax and Bcl-2 levels.

(E)-Ginsenoside F4 is a bioactive compound, specifically a type of saponin, which is derived from the root of the Panax ginseng plant. This compound is structurally characterized by its steroidal backbone with sugar moieties, which is common among ginsenosides. The mode of action of (E)-Ginsenoside F4 involves modulation of various signaling pathways, including anti-inflammatory, antioxidant, and neuroprotective mechanisms. These pathways are influenced through the inhibition of NF-κB activation and the protection against oxidative stress, which can lead to a decrease in inflammatory cytokines and an increase in cellular resilience. In terms of its applications, (E)-Ginsenoside F4 is primarily investigated for its potential therapeutic properties. It holds promise in the treatment of conditions such as inflammation, cancer, and neurodegenerative diseases. Studies have shown that it possesses cytotoxic effects against certain cancer cell lines and contributes to the enhancement of cognitive functions in neurodegenerative models. By modulating vital bioactivities, (E)-Ginsenoside F4 continues to be a focal point of research aimed at developing novel therapeutic interventions.