CAS 182431-12-5: Lomitapide
Formula:C39H37F6N3O2
InChI:InChI=1S/C39H37F6N3O2/c40-38(41,42)25-46-36(50)37(33-13-5-3-10-30(33)31-11-4-6-14-34(31)37)21-7-8-22-48-23-19-28(20-24-48)47-35(49)32-12-2-1-9-29(32)26-15-17-27(18-16-26)39(43,44)45/h1-6,9-18,28H,7-8,19-25H2,(H,46,50)(H,47,49)
InChI key:InChIKey=MBBCVAKAJPKAKM-UHFFFAOYSA-N
SMILES:C(CCCN1CCC(NC(=O)C2=C(C=CC=C2)C3=CC=C(C(F)(F)F)C=C3)CC1)C4(C(NCC(F)(F)F)=O)C=5C(C=6C4=CC=CC6)=CC=CC5
Synonyms:- 9H-Fluorene-9-carboxamide, N-(2,2,2-trifluoroethyl)-9-[4-[4-[[[4′-(trifluoromethyl)[1,1′-biphenyl]-2-yl]carbonyl]amino]-1-piperidinyl]butyl]-
- Aegr 733
- Bms 201038
- Bms 201038-01
- Bms 201238
- Lojuxta
- Lomitapide
- N-(2,2,2-Trifluoroethyl)-9-[4-[4-[[[4′-(trifluoromethyl)[1,1′-biphenyl]-2-yl]carbonyl]amino]-1-piperidinyl]butyl]-9H-fluorene-9-carboxamide
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Found 8 products.
Lomitapide-d8
CAS:Controlled ProductFormula:C39D8H29F6N3O2Color and Shape:NeatMolecular weight:701.77Lomitapide
CAS:Lomitapide (AEGR-733) blocks MTP, a key enzyme in dietary lipid absorption and VLDL assembly.Formula:C39H37F6N3O2Purity:98.91% - 99.40%Color and Shape:SolidMolecular weight:693.72Ref: TM-T6267
2mg65.00€5mg95.00€10mg145.00€25mg230.00€50mg331.00€100mg499.00€200mg717.00€500mg1,103.00€1mL*10mM (DMSO)161.00€N-(2,2,2-Trifluoroethyl)-9-(4-[4-[4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamido]piperidin-1-yl]butyl)-9H-fluorene-9-carboxamide
CAS:Lomitapide is a drug that inhibits the enzyme PCSK9, which regulates the amount of low-density lipoprotein (LDL) cholesterol in the blood. It is used to treat people with high LDL cholesterol levels who have already tried other treatments, such as diet and exercise. Lomitapide has been shown to reduce LDL-cholesterol by up to 60% in patients with primary sclerosing cholangitis and metabolic disorders. In clinical trials, lomitapide was well tolerated for up to 2 years of treatment, with side effects such as headache and diarrhea occurring at rates similar to those seen in patients taking placebo.Formula:C39H37F6N3O2Purity:Min. 95%Molecular weight:693.72 g/molRef: 3D-FT103664
Discontinued productLomitapide
CAS:Formula:C39H37F6N3O2Purity:>98.0%(HPLC)(qNMR)Color and Shape:White to Almost white powder to crystalMolecular weight:693.739H-Fluorene-9-carboxamide, N-(2,2,2-trifluoroethyl)-9-[4-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1-piperidinyl]butyl]-
CAS:Formula:C39H37F6N3O2Purity:%Color and Shape:SolidMolecular weight:693.7204
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