CAS: 1835705-74-2

Pomalidomide-PEG6-butyl iodide is an E3 ligase linker for PROTAC, combining Pomalidomide with a 6-unit PEG chain.

Pomalidomide-PEG6-butyl iodide is a compound that contains a PEG (polyethylene glycol) linker. PEGylation refers to the process of attaching PEG molecules to other substances, and in this case, Pomalidomide is linked with a PEG molecule through an amido bond. The addition of a halogenated PEG, specifically PEG iodide, enhances the stability and solubility of the compound. This heterobifunctional PEG derivative, also known as iodo PEG, is commonly used in the production of various PEG products. The incorporation of a PEG linker into Pomalidomide offers several advantages. Firstly, it improves the pharmacokinetic properties of the drug by increasing its circulation time in the body and reducing its clearance rate. Additionally, PEGylation can enhance drug delivery by improving solubility and allowing for controlled release. This modification also helps to minimize immunogenicity and reduce potential side