CAS: 185453-02-5

Applications A metabolite of Tramadol, an analgesic. References Frink, M.C., et al.: Arzneim-Forsch., 46, 1029 (1996),

Tramadol is a centrally acting analgesic that belongs to the class of opioid drugs. It is used in the treatment of moderate to severe pain and for the relief of postoperative and chronic pain. Tramadol has been shown to be effective in geriatric patients with chronic pain, but also has an effect on concentration-time curves when administered in high doses. Tramadol is metabolized by CYP2D6 into its active form, o-desmethyltramadol (ODMT), which has a longer half-life and greater potency than tramadol. This drug also interacts with other drugs, such as antidepressants, antipsychotics, anticonvulsants, and antiarrhythmics.

O-Desmethyltramadol hydrochloride is a potent inhibitor of kinases, which are enzymes that play a crucial role in cell signaling and metabolism. It has been shown to induce apoptosis in human cancer cells, making it a promising medicinal compound for the treatment of various types of tumors. O-Desmethyltramadol hydrochloride is an analog of tramadol, a commonly used pain medication. It has been found to have anticancer properties in Chinese hamster ovary cells and has also shown inhibitory effects on tumor growth in mice. This compound is excreted primarily through urine and has been tested as a potential therapeutic agent for the treatment of various cancers.