CAS 1857-19-8: 2-amino-N,N-dimethylacetamide

2-Amino-N,N-dimethylacetamide

Glycine dimethylamide is used as pharmaceutical intermediate. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

2-Amino-N,N-dimethylacetamide (2-DMA) is a molecule that has been shown to inhibit tyrosine kinase enzyme activity. It binds to the protein active site and prevents ATP from binding. 2-DMA has been shown to be effective in a variety of enzymatic assays. In addition, 2-DMA has been shown to inhibit tumor growth in human cells by blocking cell proliferation and inducing apoptosis. The inhibition of tyrosine kinase enzymes by 2-DMA may be due to its ability to reduce the amount of sulfhydryl groups on the enzyme. This leads to an increase in free sulfhydryls which can react with other functional groups, such as amines, nitrogens, or carboxyls.