CAS 18686-82-3: 1,3,4-Thiadiazole-2-thiol

2-Mercapto-1,3,4-thiadiazole is used as pharmaceutical intermediate. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

2-Mercapto-1,3,4-thiadiazole is a broad-spectrum antimicrobial agent that has been shown to be active against Gram positive and Gram negative bacteria. This compound has been shown to have an adsorption mechanism involving the formation of complexes with chloride ions, which leads to protonation of the mercapto group. 2-Mercapto-1,3,4-thiadiazole is also active against fungi and protozoa. It has been shown to have binding interactions with hydroxy groups on proteins and other biomolecules. The compound can be used as a catalyst for organic reactions that require a hydrogen bond donor such as carbon disulphide or hydrogen chloride. 2-Mercapto-1,3,4-thiadiazole does not react with water at room temperature but will react when heated in the presence of hydrochloric acid. Thermodynamic data for this reaction are available from

1,3,4-Thiadiazole-2-thiol