3-(5-Nitro-2-furyl)acrolein, with the CAS number 1874-22-2, is an organic compound characterized by its furan and acrolein moieties. It features a furan ring substituted with a nitro group at the 5-position and an acrolein side chain, which contributes to its reactivity and potential applications in organic synthesis. The presence of the nitro group enhances its electrophilic character, making it a useful intermediate in various chemical reactions, including nucleophilic additions and cycloadditions. This compound is typically a yellow to brown liquid or solid, depending on its purity and conditions. It is important to handle 3-(5-Nitro-2-furyl)acrolein with care due to its potential toxicity and reactivity. In research, it has been studied for its biological activities, including potential antitumor properties. As with many nitro-containing compounds, it may also exhibit environmental persistence, necessitating careful consideration in terms of safety and disposal.

3-(5-Nitro-2-furyl)acrolein

1874-22-2: (2E)-3-(5-nitrofuran-2-yl)prop-2-enal, (5-Nitrofuryl)acrolein, 2-(5-Nitro-2-furyl)acrolein, 2-Furanacrolein, 5-nitro-, 2-Propenal, 3-(5-nitro-2-furanyl)-, 3-(5-Nitro-2-furanyl)-2-propenal, 3-(5-Nitro-2-furyl)acrolein, 3-(5-Nitro-2-furyl)propenal, 5-Nitro-2-furanacrolein, 5-Nitro-2-furylacrolein, 5-Nitrofuracrolein, 5-Nitrofuryl-2-acrolein, Brn 0005494, Ccris 1541, β-(5-Nitro-2-furanyl)acrolein, β-(5-Nitro-2-furyl)acrolein, β-(5-Nitrofuryl)acrolein

3-(5-Nitro-2-furan)-acrolein is an aromatic compound that is a byproduct of the combustion of coal, tobacco, and other organic substances. It has been shown to be genotoxic in animal models, with typhimurium as a model organism. 3-(5-Nitro-2-furan)-acrolein binds to DNA and forms stable adducts with guanine bases. This leads to mutations in the DNA sequence when it is replicated, which can lead to cancerous cells or cell death. 3-(5-Nitro-2-furan)-acrolein also binds to proteins in the ubiquitin proteasome system and inhibits its function. This inhibition leads to higher levels of protein and DNA damage in the liver cells of rats treated with this substance.

CAS 1874-22-2: 3-(5-Nitro-2-furyl)acrolein

3-(5-Nitro-2-furan)-acrolein

Ref: 3D-FN02379

3-(5-Nitrofuran-2-yl)acrylaldehyde

Ref: 10-F320045

5-Nitrofuran-2-acrylaldehyde

Ref: IN-DA00APGF