CAS 1878-84-8: (4-Hydroxyphenoxy)acetic acid

4-Hydroxyphenoxyacetic acid (4-HPAA) is an organic acid that contains a hydroxyl group and a carboxylic acid. It is the precursor of the amino acid L-dopa, which is used in the treatment of Parkinson's disease. 4-HPAA has been shown to have tumorigenic effects in mice and also induces cell proliferation in cultured human cells. The molecular modeling study revealed that 4-HPAA binds to the growth factor receptor protein on the cell surface and activates signal transduction pathways. This leads to increased expression of basic fibroblast growth factor (bFGF). These results suggest that 4-HPAA may be involved in the process of angiogenesis, which is necessary for tumor growth.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

(4-Hydroxyphenoxy)acetic acid