CAS: 18829-83-9

Nucleoside Derivatives - 3’-Deoxy nucleosides, 5-Modified pyrimidine nucleosides, Fluoro-modified nucleosides

3’-Deoxy-5-fluorouridine is a synthetic compound that is used as an anticancer drug. It has been shown to induce apoptosis in cancer cells through the modulation of polymerase, synthetase and other enzymes involved in DNA synthesis. 3’-Deoxy-5-fluorouridine also inhibits the activity of viral thymidylate synthase, which prevents the conversion of deoxyuridine triphosphate (dUTP) to thymidylate monophosphate (dTMP), preventing DNA replication and cell division. This chemical can be synthesized by reacting uracil with trifluoroacetic acid followed by saponification.