CAS 188791-09-5: N-[3,5-Dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester dihydrochloride

(S)-Ethyl 2-(3,5-Dichloro-2-Hydroxy-4-(2-(4-Methylpiperazin-1-Yl)Ethoxy)Benzamido)-3-Phenylpropanoate Dihydrochloride

JTE-607

JTE-607 is a cytokine production inhibitor. JTE-607 induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells.

Jte 607 is a prodrug that is hydrolyzed in vivo to form the active drug, Jte 607 acid. This drug has shown cardioprotective effects in animal models by reducing the expression of proinflammatory cytokines and increasing the production of anti-inflammatory cytokines. It also inhibits tumor necrosis factor (TNF) and interleukin-1β (IL-1β), which are proinflammatory cytokines. The molecular mechanism of Jte 607 is not yet fully understood, but it may be due to its ability to induce apoptosis and inhibit DNA synthesis in tumor cells.