CAS: 189362-06-9

K 134 is a benzimidazole derivative that has been shown to be an effective inhibitor of muscle cell proliferation. K 134 inhibits the activity of fatty acid synthase and prevents the synthesis of eicosanoids, which are important mediators of inflammation. The inhibition of fatty acid synthase by K 134 may be due to its ability to bind to the active site and competitively inhibit the binding of acetyl-CoA. K 134 also has a dry weight-increasing effect on gastrocnemius muscle cells in rats, which is due to its ability to inhibit protein degradation as well as stimulate protein synthesis. K 134 has been shown to be effective against P. aeruginosa in a primary analysis and in vitro experiments, but it is not yet known whether this drug will be effective for humans.

K134 is an inhibitor of phosphodiesterase 3. The IC50s of K134 for PDE3A, PDE3B, PDE5, PDE2 and PDE4 are 0.1, 0.28, 12.1, >300 and >300 μM, respectively.