CAS 19012-03-4: 1-Methylindole-3-carboxaldehyde

1-Methyl-1H-indole-3-carboxaldehyde

1-Methylindole-3-carboxaldehyde is used as a reactant for preparation of nitroolefins and β-nitroalcohols via microwave- or ultrasound-assisted Henry reactions, reactant for synthesis of quinolinones via three-component Ugi reaction, reactant for synthesis of α-ketoamides as inhibitors of Dengue virus protease with antiviral activity in cell-culture, reactant for preparation of thiazolopyrimidinones as inhibitors of Bcl-2 proteins, reactant for preparation of vinylindoles via Peterson olefination or olefination with Nysted reagent, reactant for preparation of indolyl alkenes from microwave-enhanced Knoevenagel condensation as antibacterial agents 1-Methylindole-3-carboxaldehyde may be used in the synthesis of (Z)-3-(1-methyl-1H-indol-3-yl)-2-(thiophen-3-yl)acrylonitrile, via base-catalyzed condensation with thiophene-3-acetonitrile. It was also used in the preparation of monomer, required for the synthesis of poly(3-vinyl-1-methylindole). This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

1-Methylindole-3-carboxaldehyde is a molecule with an amide bond and a methyl group. The amide bond is formed by the reaction between an amide and an acid chloride, while the methyl group is derived from a methylene. 1-Methylindole-3-carboxaldehyde has been shown to inhibit tumor growth in hepg2 cells. This compound can be used as a potential cancer drug because it inhibits the production of tumor cell lines through the inhibition of protein synthesis. It also has low energy vibrations that can be used for vibrational spectroscopy, fluorescence properties that make it useful for optical imaging, and active methylene groups that may be used for synthesizing other molecules.