CAS: 1911579-04-8

GS-704277, a Remdesivir metabolite, shows potent in vitro effects against COVID-19.

GS-704277 is a small molecule antiviral drug that has been shown to inhibit the replication of influenza virus. GS-704277 is an orally bioavailable prodrug that undergoes metabolism in the liver to its active form, GS-742. This compound inhibits viral RNA synthesis by binding to the viral polymerase and inducing conformational changes in the enzyme that disrupt its ability to synthesize viral RNA. GS-704277 has been shown to have a low potential for human toxicity and is effective against a wide range of viruses.