CAS 192441-08-0: Lomeguatrib
Formula:C10H8BrN5OS
InChI:InChI=1S/C10H8BrN5OS/c11-5-1-6(18-3-5)2-17-9-7-8(14-4-13-7)15-10(12)16-9/h1,3-4H,2H2,(H3,12,13,14,15,16)
InChI key:InChIKey=JUJPKFNFCWJBCX-UHFFFAOYSA-N
SMILES:O(CC1=CC(Br)=CS1)C2=C3C(=NC(N)=N2)N=CN3
Synonyms:- 1H-Purin-2-amine, 6-[(4-bromo-2-thienyl)methoxy]-
- 2-Amino-6-(4-bromothiophen-2-ylmethoxy)-9H-purine
- 2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purine
- 6-[(4-Bromo-2-thienyl)methoxy]-9H-purin-2-amine
- 6-[(4-bromothiophen-2-yl)methoxy]-7H-purin-2-amine
- 9H-Purin-2-amine, 6-[(4-bromo-2-thienyl)methoxy]-
- PaTrin 2
- Lomeguatrib
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Found 4 products.
9H-Purin-2-amine, 6-[(4-bromo-2-thienyl)methoxy]-
CAS:Formula:C10H8BrN5OSPurity:98%Color and Shape:SolidMolecular weight:326.1724Lomeguatrib
CAS:Inhibitor and pseudosubstrate of DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT). It is used as a sensitizer for the treatment of advanced solid tumors, including prostate, colorectal and central nervous system malignancies. Lomeguatrib inhibits the repair mechanism of DNA damage induced by alkylating agents such as temozolomide, and therefore potentiates its anti-cancer effects.Formula:C10H8BrN5OSPurity:Min. 95%Color and Shape:SolidMolecular weight:324.96329Lomeguatrib
CAS:Lomeguatrib (PaTrin-2), a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .Formula:C10H8BrN5OSPurity:99.26% - 99.62%Color and Shape:SolidMolecular weight:326.17
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