CAS 19365-08-3: 3-hydroxypiperidin-2-one

3-Hydroxy-2-piperidinone

3-Hydroxypiperidin-2-one is a chiral molecule that is composed of two stereoisomers. It has been shown to inhibit the activity of cytochrome P450 2E1, which is involved in the metabolism of some drugs and other xenobiotics. 3-Hydroxypiperidin-2-one also inhibits the growth of tuberculosis bacteria and fungus Aspergillus niger. This compound is a low molecular weight, hydrophobic molecule that can be synthesized from L-glutamic acid and piperidine. The synthesis process involves three steps: 1) condensation with sodium cyanide to form 2,4-dichlorobenzyl alcohol; 2) reaction with hydrogen chloride to form chloroacetyl chloride; 3) reaction with piperidine to form 3-hydroxypiperidin-2-one. This process can be scaled up for industrial production.