CAS 194032-33-2: 4-Fluoro-5-isoquinolinesulfonyl chloride

4-Fluoroisoquinoline-5-sulfonyl chloride

4-Fluoroisoquinoline-5-sulfonyl chloride is a coupling agent that can be used in intramolecular reactions. It is an isoquinoline derivative with a sulfonyl chloride substituent, which has the ability to form hydrogen bonds and steric effects. In the presence of a base, 4-fluoroisoquinoline-5-sulfonyl chloride undergoes an electrophilic substitution reaction at the 4 position to form an intermediate sulfonium ion. The conformational geometry of this intermediate is determined by the substituents on the phenyl ring and on the sulfur atom. The steric effect of these substituents dictates whether the product will have one or two conformations, namely E or Z configuration. The final conformation is dependent on subsequent reactions and conditions.