Monosialoganglioside G(M2), also known as GM2, is a glycosphingolipid primarily found in the brain and nervous tissue of mammals, including bovine sources. It is characterized by its structure, which consists of a ceramide backbone linked to a sialic acid-containing oligosaccharide chain. GM2 plays a crucial role in cell recognition and signaling processes within the nervous system. Its presence is particularly significant in the context of neuronal membranes, where it contributes to the stability and functionality of lipid rafts. The CAS number 19600-01-2 identifies this specific compound, facilitating its recognition in chemical databases. GM2 is also notable for its involvement in certain metabolic disorders, such as Tay-Sachs disease, where its accumulation due to enzyme deficiencies leads to neurodegeneration. The study of GM2 and its derivatives is essential for understanding various neurological functions and potential therapeutic approaches for related diseases.

monosialoganglioside G(M2) from bovine brain

19600-01-2: GM2, GM2-ganglioside, GM2, GM2-Ganglioside, Ganglioside A1, Ganglioside A1, Ganglioside G5, Ganglioside G5, Ganglioside GM2, Ganglioside GO, Ganglioside GM2, Ganglioside GO, Ganglioside M2, Sialosylganglio-N-triaosylceramide, Tay-Sachs ganglioside, Monosialoganglioside GM2 bovine brain

GM2 ganglioside (sodium salt) has a core trisaccharide structure (GalNAcÎ²1,4GalÎ²1,4Glc) with sialic acid linked Î±2,3 to the central galactose residue and ceramide linked Î² to position 1 on the reducing terminal glucose residue (Ledeen, 2009).  GM2 ganglioside is present on neuronal cells and plays a key role in the regulation of dendritogenesis in cortical pyramidal neurons. In lysosomal storage disorders, such as, Tay-Sachs and Sandhoff disease, where hexosaminases A and B are deficient, GM2 ganglioside accumulates in the nervous system (Cachon-Gonzalez, 2018). GM2 ganglioside is also overexpressed in melanomas and other tumours of neuro-ecto origin (Yoshida, 2020). Moreover, the sugar moiety of the GM2 ganglioside is a receptor allowing the viral infection of cells with reovirus and rotavirus (Zhu, 2018).

GM2-Ganglioside

GM2 is a glycosphingolipid in cell membranes, high in Sandhoff, Tay-Sachs, Niemann-Pick A, C1, C2, and some lysosomal storage diseases.

CAS 19600-01-2: monosialoganglioside G(M2) from bovine brain

GM2-Ganglioside

Ref: 3D-OG16187

Ganglioside GM2 Mixture (sodium salt)

Ref: TM-T35930

Monosialoganglioside GM2 (human)

Ref: 48-56-1200

GM2-Ganglioside

Ref: 7W-GC6057

GM2-Ganglioside

Ref: IN-DA01EAO7