CAS 19666-76-3: Panaxadiol

Panaxadiol , a ginseng saponin with a dammarane skeleton, selectively interferes with the cell cycle in human cancer cell lines, it inhibits DNA synthesis in a dose-dependent manner with IC50 values ranging from 0.8 to 1.2 μM in SK-HEP-1 cells and HeLa cells, it selectively elevates p21WAF1/CIP1 levels and thereby arrests the cell cycle at G1/S phase by down-regulating Cyclin A-Cdk2 activity.

Panaxadiol is a bioactive compound, classified as a dammarane-type tetracyclic triterpenoid, which is derived from ginseng, specifically from the plant species Panax ginseng. Its structure and chemical properties are extracted and isolated from the roots of this medicinal plant using advanced phytochemical methods. Panaxadiol functions primarily through its interaction with cellular pathways, modulating key signaling mechanisms, including antioxidant and anti-inflammatory processes. It has been shown to influence apoptosis, the programmed cell death pathway, which is a critical factor in controlling cell proliferation and cancer development. Applications of Panaxadiol extend to various therapeutic domains. Research has highlighted its potential efficacy in oncology, where it may serve as an adjunct in cancer therapy by enhancing the effects of chemotherapeutic agents while reducing their side effects. Additionally, its role in neuroprotection has been explored, providing insights into the treatment of neurodegenerative diseases. The compound's ability to modulate immune responses also underscores its potential use in managing chronic inflammatory conditions. These findings suggest a promising future for Panaxadiol in advancing medical science and therapeutic interventions.

Applications Panaxadiol is the purified sapogenin of ginseng saponins, which exhibits anti-tumor activity. Research has shown Panaxadiol exhibited enhancing activity towards human colorectal cancer cells. References Li, X.L., et al.: Cancer. Chemotherap. Pharmacol., 64, 1097 (2009); Jung, H.K., et al.: J, Ginseng. Res., 33, 26 (2009);

Oxygen-heterocyclic compound

Panaxadiol

Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.