CAS 19685-09-7: Hydroxycamptothecin
Formula:C20H16N2O5
InChI:InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3/t20-/m0/s1
InChI key:InChIKey=HAWSQZCWOQZXHI-FQEVSTJZSA-N
SMILES:O=C1N2C(C=3C(C2)=CC=4C(N3)=CC=C(O)C4)=CC5=C1COC(=O)[C@@]5(CC)O
Synonyms:- (+/-)-4-Ethyl-4,9-Dihydroxy-1H-Pyrano[3',4':6,7]Indolizino[1,2-B]Quinoline-3,14(4H,12H)-Dione
- (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- (4S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- 10-Hcpt
- 10-Hydroxy Camptothecin
- 10-Hydroxycamptothecin
- 10-Hydroxycamptothecine
- 10Hydroxy Camptothecin
- 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-, (4S)-
- 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-, (S)-
- 7-Ethy Hydroxycamptothecin
- See more synonyms
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Found 15 products.
(4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
CAS:Formula:C20H16N2O5Purity:%Color and Shape:SolidMolecular weight:364.351410-Hydroxy Camptothecin
CAS:Controlled ProductImpurity Irinotecan USP Related Compound A Applications A Camptothecin derivative; a topoisomerase inhibitor for cancer therapy. Irinotecan USP Related Compound A Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Wani, M.C., et al.: J. Med. Chem., 29, 2358 (1986), Miller, K.D., et al.: Invest. New Drugs, 22, 69 (2004), Punt, C.J.A., et al.: Eur. J. Cancer, 40, 1332 (2004), Wang, J.-Q., et al.: Bioorg. Med. Chem., 13, 549 (2005),Formula:C20H16N2O5Color and Shape:YellowMolecular weight:364.35Irinotecan Related Compound A ((S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione)
CAS:Other alkaloids,natural or reproduced by synthesis, and their salts, ethers,esters&other derivatives, nesoiFormula:C20H16N2O5Color and Shape:Light Yellow PowderMolecular weight:364.1059210-Hydroxycamptothecin
CAS:10-Hydroxycamptothecin is an alkaloid, which is derived from the bark and stem of the Camptotheca acuminata tree, commonly known as the "Happy Tree." This compound is a potent topoisomerase I inhibitor. Its mode of action involves binding to the topoisomerase I-DNA complex, stabilizing it and thus preventing the re-ligation of DNA single-strand breaks. This interruption in the DNA replication process leads to DNA damage, ultimately triggering apoptosis in rapidly dividing cells. 10-Hydroxycamptothecin is primarily explored for its anticancer properties. It shows significant efficacy against various cancer cell lines, including those related to colorectal, ovarian, and lung cancers. Its unique mechanism of action, targeting the DNA processing enzymes, makes it a valuable compound in oncological research for developing chemotherapeutic agents. However, its clinical application is limited by solubility and stability challenges, necessitating further research into formulation and delivery methods to enhance its therapeutic potential and minimize side effects.Formula:C20H16N2O5Purity:Min. 95%Color and Shape:PowderMolecular weight:364.35 g/mol(S)-10-Hydroxycamptothecin
CAS:(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.Formula:C20H16N2O5Purity:99.09% - 99.81%Color and Shape:SolidMolecular weight:364.35Irinotecan EP Impurity B (Irinotecan USP Related Compound A, 10-Hydroxy Camptothecin)
CAS:Formula:C20H16N2O5Molecular weight:364.3610-Hydroxycamptothecin
CAS:Formula:C20H16N2O5Purity:>98.0%(HPLC)Color and Shape:White to Yellow to Orange powder to crystalMolecular weight:364.36
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