CAS 197250-15-0: GAP 26

Gap 26

GAP26 corresponds to residues 63-75 of connexin 43, a gap junction-blocking transmembrane protein. GAP26 attenuates the rhythmic contractile activity of rabbit arterial smooth muscle (IC₅₀ 28.4 mM). The peptide also inhibits IP3-induced ATP release without inhibiting gap junctional coupling in endothelial cells.

Gap 26 is a mimetic peptide corresponding to the residues 63-75 of connexin 43, which is a gap junction blocker.

13-mer connexin mimetic peptide, composed of residue numbers 63-75 of the first extracellular loop of connexin 43 (gap junction blocker), containing the SHVR amino acid motif.

corresponds to residues 63-75 of connexin 43, a gap junction-blocking transmembrane protein. GAP26 attenuates the rhythmic contractile activity of rabbit arterial smooth muscle. The peptide also inhibits IP3-induced ATP release without inhibiting gap junctional coupling in endothelial cells.