CAS 199926-39-1: 4-Oxo-1,4-dihydropyridine-2,6-dicarboxylicacidhydrate

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

4-Oxo-1,4-dihydropyridine-2,6-dicarboxylic acid hydrate (4ODHC) is a molecule that is being investigated as a potential anti-cancer drug. It is a trifluoroacetic acid derivative of lactic acid and has been shown to be highly selective for cancer cells with high glutamate levels. 4ODHC also binds to nitrogen atoms, which are found in the amino acids glutamine and asparagine, both of which are important for cancer cell proliferation. The radionuclide properties of 4ODHC make it useful as an optical imaging probe. The pyrazole ring on the molecule can target mammalian tissue and the hydroxy group on the molecule can bind to monoclonal antibodies (mAbs).

4-Oxo-1,4-dihydropyridine-2,6-dicarboxylic acid hydrate