Fmoc-L-Glu(2-phenylisopropyloxy)-OH is a derivative of the amino acid glutamic acid, modified to include a 9-fluorenylmethoxycarbonyl (Fmoc) protecting group and a 2-phenylisopropyloxy side chain. This compound is typically used in peptide synthesis, particularly in solid-phase peptide synthesis, where the Fmoc group serves as a protective group for the amino group of the glutamic acid residue. The presence of the 2-phenylisopropyloxy moiety enhances the compound's hydrophobic characteristics, which can influence the solubility and stability of peptides during synthesis. The compound is characterized by its ability to participate in peptide bond formation while maintaining the integrity of the Fmoc group until deprotection is required. Its molecular structure contributes to its reactivity and compatibility with various coupling reagents used in peptide synthesis. Overall, Fmoc-L-Glu(2-phenylisopropyloxy)-OH is a valuable building block in the field of peptide chemistry, facilitating the synthesis of complex peptides with specific functional properties.

Fmoc-L-Glu(2-phenylisopropyloxy)-OH

200616-39-3: N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-glutamic acid 5-(1-methyl-1-phenylethyl) ester, Fmoc-Glu(O-2-Phipr)-Oh

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Fmoc-L-glutamic acid γ -2-phenylisopropyl ester

Fmoc-Glu(O-2-PhiPr)-OH

L-Glutamic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 5-(1-methyl-1-phenylethyl) ester

Fmoc -Glu (O-2 PhiPr) OH

Glu-derivative for the selective modification of the γ-carboxyl group. The OPp group can be removed selectively in the presence of Boc/OtBu with 1% TFA/DCM.  Ocampo et al. applied OPp protection during the synthesis of a peptide-oligonucleotide conjugate and cleaved it with 3% trichloroacetic acid in DCM. Tofteng et al. generated a backbone pyroglutamyl imide moiety from C-terminal Glu after selective on-resin OPp removal.

CAS 200616-39-3: Fmoc-L-Glu(2-phenylisopropyloxy)-OH

Fmoc-L-glutamic acid γ -2-phenylisopropyl ester

Ref: 3D-FF48581

Fmoc-Glu(O-2-PhiPr)-OH

Ref: 54-OR36410

L-Glutamic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 5-(1-methyl-1-phenylethyl) ester

Ref: IN-DA002CVD

Fmoc -Glu (O-2 PhiPr) OH

Ref: 10-F541631

Fmoc-Glu(2-phenylisopropyl ester)-OH

Ref: 01-4025419